Rheumatology fellows and advanced trainees participate in the numerous clinical trials ongoing at the NIH Clinical Center, the country's largest medical center exclusively devoted to clinical research. Patients are recruited into the NIH clinical trials not only from the local area, but nationally, and even internationally, depending on the rarity of the disease under study. Clinical studies at the NIH fall into two categories:
Our investigational clinical trials tend to be early stage phase II trials that also test hypotheses about disease mechanisms, rather than large, later stage company-sponsored multi-center trials.
A listing of current clinical trials at the NIAMS can be found here.
See patients enrolled in a NIAMS lupus trial and a vasculitis trial tell their stories:
Clinical and translational researchers at the NIAMS and other Institutes at the NIH have made major contributions to the understanding and treatment of rheumatic disease over many years. The use of cyclophosphamide to treat vasculitis and lupus nephritis, which has become part of the standard of care around the world, was pioneered at the NIH in the 1970s and 1980s. Under the leadership of our faculty member Dr. Dan Kastner, the genetic causes of and recognition of the shared features of diseases now known as autoinflammatory diseases were discovered. Many of these discoveries were celebrated during the 25th anniversary of the founding of the NIAMS in 2011, and an interactive timeline of those discoveries can be found on the NIAMS 25th Anniversary Milestones. Noteworthy discoveries made at the NIH in rheumatic diseases include:
New findings and discoveries in rheumatic diseases are highlighted in the NIAMS IRP News Page and the NIAMS Intramural Research Program Facebook page External link, please review our exit disclaimer..